First uterus transplant in U.S. fails amid 'sudden complication'

The first uterus transplant in the U.S. failed after the patient experienced a “sudden” complication, Cleveland Clinic announced Wednesday.

The surgery, which took place on Feb. 24 in Cleveland, initially seemed to be a success.

“We are saddened to share that our patient, Lindsey, recently experienced a sudden complication that led to the removal of her transplanted uterus,” the Cleveland Clinic said in a statement. 

The 26-year-old recipient identified only as Lindsey is doing well and recovering, according to the clinic.

“I just wanted to take a moment to express my gratitude towards all of my doctors,” Lindsey said in a statement. They acted very quickly to ensure my health and safety. Unfortunately, I did lose the uterus to complications. However, I am doing okay and appreciate all of your prayers and good thoughts

Lindsey is part of a research study which will include ten women who have uterine factor infertility (UFI) or cannot carry a child because they were born without a uterus.

According to the clinic, there is a known risk that a transplanted organ may have to be removed if complications occur following the surgery. Doctors are currently looking into what factors contributed to Lindsey's complications.

While the uterus transplant marks a first in the U.S., there have been successful uterus transplants in Sweden. 

A woman in Sweden born without a uterus received one in 2013 from a 61-year-old post-menopausal woman, according to research published in the journal The Lancet. 

She later gave birth, offering the first “proof-of-concept for uterus transplantation as a treatment for uterine factor infertility,” according to the report.

UFI affects thousands of women worldwide. Some women are born without a uterus, and others can acquire UFI after a hysterectomy or a serious pelvic infection, according to the clinic.

Despite the setback, the Cleveland Clinic plans to continue screening candidates for the procedure.

“The study … is still ongoing with a commitment to the advancement of medical research to provide an additional option for women and their families,” the clinic said in a statement.

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